Applications are invited from outstanding early-career scientists for a Research Associate post working with Professor Albert Ong and Dr Andrew Streets (Academic Nephrology Unit) on an exciting project recently funded by Kidney Research UK and the Polycystic Kidney Disease Charity to develop new treatments for autosomal dominant polycystic kidney disease (ADPKD).
ADPKD is the major genetic disease leading to kidney failure in man and affects around 1 in 1000 people. In the UK, around 70,000 patients are affected and around 8-9 million individuals globally. The project will first examine a new hypothesis that cytoskeletal dysregulation is a key driver of cyst initiation in ADPKD. Second, promising candidate molecules with the potential to correct the phenotype will be tested using in vitro assays (3D human cysts, human iPS kidney organoids) and in vivo preclinical disease models.
The scientific goals of these experiments are to clarify the molecular basis of cyst formation and to identify a lead compound to take into a future clinical trial.
The post will provide an excellent opportunity to undertake high quality cutting-edge research with one of the world’s leading research groups in the field.
We are looking for a passionate, creative and ambitious early career researcher with a strong interest in translational research and a solid proven background in cell biology, molecular biology, protein biochemistry and bioinformatics. Prior hands-on experience in the use of in vivo preclinical disease models would be an advantage. The post is full-time and fixed-term for 36 months in the first instance.
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