Research Associate- Structural Biology

Job Description

Job summary

We are seeking a highly motivated candidate to fill the post of Research Associate, Structural Biology within the Department of Life Sciences at Imperial College London.

You will be joining the research group of Professor Erhard Hohenester, who is studying the molecular mechanisms underlying extracellular matrix assembly and function (please visit for further information). You will be investigating the enzymes involved in proteoglycan biosynthesis. In particular, you will develop methods for the chemo-enzymatic synthesis of glycopeptides for structural studies. This project is a unique opportunity to work at the interface of chemical and structural biology.

Duties and responsibilities

You will be responsible for the following:

To take initiative in planning and executing experiments to advance the research project
To direct the work of small research teams including undergraduate and postgraduate students
To identify and develop suitable techniques, and apparatus, for the collection and analysis of data
To communicate your findings in oral and written formats at lab meetings and conferences
To draft publications and prepare them for submission to refereed journals
To contribute to writing bids for research grants
To assist with the supervision of undergraduate and postgraduate students
To develop contacts and research collaborations within the College and wider community

Essential requirements

You will have a PhD (or equivalent) in Biochemistry or a related subject

Experience in the following is essential:

An internationally competitive research environment

Standard molecular biology techniques

Protein expression (ideally in mammalian cell culture)

Protein purification and characterisation

Knowledge of enzymes structures and mechanisms is also essential along with a demonstrable knowledge of a sound understanding of protein structure.

Experience in X ray crystallography is not required but would be a distinct advantage.

You must have experience of working in a team, the ability to develop and apply new concepts and have a creative approach to problem-solving. You must also have excellent verbal and written communication skills and be able to organise your own work with minimal supervision and prioritise in response to deadlines.

Further information

This is a full time, fixed-term post until 31 August 2019.

*Candidates who have not yet been officially awarded their PhD, will be appointed as a Research Assistant within the salary range £32,380 – £34,040 per annum

Should you require any further details on the role please contact: Professor Erhard Hohenester ( ).

Should you have any queries about the application process please contact Peggy Baker by email at and refer to the job reference number.

For technical queries when applying online, please contact